Total integrated dose testing of solid-state scientific CD4011, CD4013, and CD4060 devices by irradiation with CO-60 gamma rays

The total integrated dose response of three CMOS devices manufactured by Solid State Scientific has been measured using CO-60 gamma rays. Key parameter measurements were made and compared for each device type. The data show that the CD4011, CD4013, and CD4060 produced by this manufacturers should not be used in any environments where radiation levels might exceed 1,000 rad(Si)

Computational modelling and experimental characterisation of heterogeneous materials

Heterogeneous materials can exhibit behaviour under load that cannot be described by classical continuum elasticity. Beams in bending can show a relative stiffening as the beam depth tends to zero, a size effect. Size effects are recognised in higher order continuum elastic theories such as micropolar elasticity. The drawback of higher order theories is the requirement of addition constitutive relations and associated properties that are often difficult to establish experimentally. Furthermore the finite element method, of great benefit in classical elasticity, has shown limitations when applied to micropolar elasticity. The determination of additional constitutive properties and the computational modelling of micropolar elasticity will be discussed in the context of a model heterogeneous material loaded in simple 3 point bending. The model material was created by drilling holes in aluminium bar in a regular pattern, with the hole axis normal to the plane of bending. The bending tests show that a size effect is present. These results are compared against modelling the detailed beam geometries in the finite element package ANSYS, which again shows the size effect. These two bending test are used to extract the additional micropolar elastic material properties. A comparison is then made against analytical solutions,numerical solutions using a micropolar beam finite element and a micropolar plane stress control volume method.It will be shown that the need for extensive experimental testing to determine the additional constitutive properties may not be necessary with the appropriate use of numerical methods

L'impact des changements technologiques sur le travail de Paul Baillargeon dans la série Star Trek

La version intégrale de ce mémoire est disponible uniquement pour consultation individuelle à la Bibliothèque de musique de l’Université de Montréal (www.bib.umontreal.ca/MU).Le compositeur canadien Paul Baillargeon a réalisé la musique de plus de quarante épisodes des séries télévisées Star Trek, maintenant traduites et diffusées à travers le monde. Star Trek est l’une des dernières séries télévisuelles américaines ayant utilisé un orchestre symphonique d’envergure avant que ses principaux compositeurs réalisent eux-mêmes leurs bandes sonores à l’aide d’ordinateurs et d’échantillons numériques, remplaçant ainsi la cinquantaine de musiciens qui perpétuait la tradition acoustique de la production musicale à Hollywood. Non seulement ces outils influencent-ils la musique de Paul Baillargeon, mais ils transforment aussi son travail au sein de la postproduction des populaires séries télévisées. Ce regard microscopique sur l’influence des technologies musicales dans la création télévisuelle s’inscrit dans un contexte plus vaste qui concerne les transformations culturelles et sociales issues des rapides progrès technologiques auxquelles nous assistons depuis deux décennies.Canadian composer Paul Baillargeon wrote the music for more than forty television shows for the Star Trek series, now translated and broadcasted around the world. Star Trek was one of the last television series produced by a complete symphonic orchestra when Paul Baillargeon started using computers and digital samples, thereby replacing those musicians that were perpetuating Hollywood’s acoustical tradition. Not only do these tools affect the music of Paul Baillargeon, they also transform his work among the postproduction team of the popular television series. This close look at how musical technology influences composition and music production for that particular composer is part of a vast context in which technological progress has transformed our cultural and social fields for the past two decades

A Roadmap to Health Insurance for All: Principles for Reform

Presents principles for health insurance reform and compares the potential of three approaches -- tax incentives for the individual insurance market; mixed private-public group insurance with shared financing responsibility; and public insurance

High-order optical nonlinearity at low light levels

We observe a nonlinear optical process in a gas of cold atoms that simultaneously displays the largest reported fifth-order nonlinear susceptibility \chi^(5) = 1.9x10^{-12} (m/V)^4 and high transparency. The nonlinearity results from the simultaneous cooling and crystallization of the gas, and gives rise to efficient Bragg scattering in the form of six-wave-mixing at low-light-levels. For large atom-photon coupling strengths, the back-action of the scattered fields influences the light-matter dynamics. This system may have important applications in many-body physics, quantum information processing, and multidimensional soliton formation.Comment: 5 pages, 3 figure

Therapeutic Potential of Mesenchymal Stem Cells for Cancer Therapy

Mesenchymal stem cells (MSCs) are among the most frequently used cell type for regenerative medicine. A large number of studies have shown the beneficial effects of MSC-based therapies to treat different pathologies, including neurological disorders, cardiac ischemia, diabetes, and bone and cartilage diseases. However, the therapeutic potential of MSCs in cancer is still controversial. While some studies indicate that MSCs may contribute to cancer pathogenesis, emerging data reported the suppressive effects of MSCs on cancer cells. Because of this reality, a sustained effort to understand when MSCs promote or suppress tumor development is needed before planning a MSC-based therapy for cancer. Herein, we provide an overview on the therapeutic application of MSCs for regenerative medicine and the processes that orchestrates tissue repair, with a special emphasis placed on cancer, including central nervous system tumors. Furthermore, we will discuss the current evidence regarding the double-edged sword of MSCs in oncological treatment and the latest advances in MSC-based anti-cancer agent delivery systems.Junta de Andalucía PI-0272-2017Ministerio de Ciencia, Innovación y Universdad CD16/00118, CP19/00046, PI16/00259, BFU2017-83588-P, CP14/00105, PI18/01590, PI17/02104, PIC18/0010, IC19/0052Juvenile Diabetes Research Foundation (USA) 2-SRA-2019-837-S-BFundación Española para la Ciencia y la Tecnología 2018-00023

Waveguide QED: Many-Body Bound State Effects on Coherent and Fock State Scattering from a Two-Level System

Strong coupling between a two-level system (TLS) and bosonic modes produces dramatic quantum optics effects. We consider a one-dimensional continuum of bosons coupled to a single localized TLS, a system which may be realized in a variety of plasmonic, photonic, or electronic contexts. We present the exact many-body scattering eigenstate obtained by imposing open boundary conditions. Multi-photon bound states appear in the scattering of two or more photons due to the coupling between the photons and the TLS. Such bound states are shown to have a large effect on scattering of both Fock and coherent state wavepackets, especially in the intermediate coupling strength regime. We compare the statistics of the transmitted light with a coherent state having the same mean photon number: as the interaction strength increases, the one-photon probability is suppressed rapidly, and the two- and three-photon probabilities are greatly enhanced due to the many-body bound states. This results in non-Poissonian light.Comment: 10 page